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 Ankylosing Spondylitis     October 25, 2014  
Ankylosing Spondylitis, Spondyloarthritis and HLA-B27
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  • AS and related SpA have a predilection for inflammation at sites where the tendons and ligaments attach to the bones (enthesitis), especially in the sacroiliac joints and the spinal column. The symptoms usually start during late teens or early twenties (rarely after age 45), and is 2 to 3 times more common in males. (read full article)
 
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ASIM also happens to be the middle (given) name of the chief consultant for this website, Professor Muhammad Asim Khan, MD, who has suffered from severe form of AS himself for 57 years.

Disclaimer: This information is provided for general medical education purposes only and is not meant to substitute for the independent medical judgment of a physician relative to diagnosis and treatment options of a specific patient’s medical condition. This information does not represent an endorsement by ASIM or this website or its consultants. In no event will ASIM or this website or its consultants be liable for any decision made or action taken in reliance upon the information provided through this website.

 
Ankylosing Spondylitis (AS) and Spodyloarthritis (SpA)
  • The name ankylosing spondylitis is derived from Greek roots angkylos = ”bent” (although the word ankylosis now means joint stiffening or fusion) and spondylos = ”spinal vertebra”.
  • It is a chronic, inflammatory rheumatic disease with a prevalence of about 0.5% in epidemiologic studies in Europe, but the prevalence can vary in other populations.
  • It is the prototype of a group of diseases that share clinical and pathogenetic features and are grouped under the term "Spondyloarthritis" or "Spondyloarthropathies" (SpA). This term includes, in addition to AS, reactive SpA, psoriatic SpA, enteropathic SpA (associated with Crohn's disease and ulcerative colitis) and undifferentiated SpA.
  • These diseases can occur within families because of a strong genetic predisposition highlighted by its strong association with HLA-B27, a normal gene that is also present in a small percentage of the general population.
For Patients: What is Ankylosing Spondylitis a Nutshell?
      Excerpted from:    Ankylosing Spondyitis: the Facts                 Ankylosing Spondylitis

Ankylosing spondylitis (or “AS” for short) is a chronic (progressive) painful inflammatory rheumatic disease which affects the spinal joints, in particular those at the base of the spine (the sacroiliac (SI) joints  and the lumbar spine), with resultant chronic back pain and stiffness. These symptoms typically start at young age, beginning between the ages of 15 and 30; the mean age of onset is 24 years (range 8-45). It is very uncommon for the symptoms to begin after age 45. The most common first symptom is chronic low back pain and stiffness of gradual (insidious) onset. It can take many years, on average about 7 years, before the correct diagnosis. (read full article)

Areas of Inflammation in Ankylosing Spondylitis
 
2012 July 9 Asim Radio Interview
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