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 Ankylosing Spondylitis     May 25, 2018  

New Book

Brief Bio-Sketch:
Dr. Khan obtained his medical degree in 1965 and after 2 years of Army Service, he obtained his postgraduate training in the UK and the US. After completing his rheumatology fellowship in Cleveland, OH in 1973, he joined the faculty of Case Western Reserve University in that city. He served till 2012 as a fully tenured Professor of Medicine when he was awarded the title of Professor Emeritus of Medicine, and in 2015 he was inducted into the Medical Hall of Honor at MetroHealth Medical Center, the hospital he has served since 1971.

His research interests focus on clinical, genetic, and therapeutic aspects of rheumatic diseases, and has special interest in ankylosing spondylitis (AS) and related forms of spondyloarthritis (SpA). He has authored 3 books on AS, edited two additional books and a monograph, and authored or coauthored 47 book chapters, and 236 scientific articles. He is the Section Editor (Spondyloarthritis) for Current Rheumatology Report, and a peer reviewer for UpToDate. He has served on the editorial board and as peer reviewer of many scientific journals, and is a founding member of ASAS, SPARTAN, and GRAPPA, the three premier international organizations interested in research in AS/SpA.

Dr. Khan was elected as a Master of both the ACP (MACP) and the ACR (MACR), and a Fellow of the Royal College of Physicians of UK (FRCP). He had served as a member of the National Advisory Board for the National Institute of Arthritis and Musculoskeletal and Skin Disorders (NIAMS). He is a recipient of the ACR’s Distinguished Rheumatologist Award, SPARTAN’s Lifetime Achievement Award, and SAA’s Greg Field Award that is given to "individuals with AS who have persevered and gone on to be of service to others”.
ASIM: Ankylosing Spondylitis Information Mission ©
Ankylosing Spondylitis Information Movement ©
Ankylosing Spondylitis Information Matrix ©
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Ankylosing Spondylitis International Mission ©
ASIM also happens to be the middle (given) name of the chief consultant for this website, Professor Muhammad Asim Khan, MD, who has suffered from severe form of AS himself for 59 years.

Disclaimer: This information is provided for general medical education purposes only and is not meant to substitute for the independent medical judgment of a physician relative to diagnosis and treatment options of a specific patient’s medical condition. This information does not represent an endorsement by ASIM or this website or its consultants. In no event will ASIM or this website or its consultants be liable for any decision made or action taken in reliance upon the information provided through this website.

Ankylosing Spondylitis (AS) and Spodyloarthritis (SpA)
  • The name ankylosing spondylitis is derived from Greek roots angkylos = ”bent” (although the word ankylosis now means joint stiffening or fusion) and spondylos = ”spinal vertebra”.
  • It is a chronic, inflammatory rheumatic disease with a prevalence of about 0.5% in epidemiologic studies in Europe, but the prevalence can vary in other populations.
  • It is the prototype of a group of diseases that share clinical and pathogenetic features and are grouped under the term "Spondyloarthritis" or "Spondyloarthropathies" (SpA). This term includes, in addition to AS, reactive SpA, psoriatic SpA, enteropathic SpA (associated with Crohn's disease and ulcerative colitis) and undifferentiated SpA.
  • These diseases can occur within families because of a strong genetic predisposition highlighted by its strong association with HLA-B27, a normal gene that is also present in a small percentage of the general population.
For Health Professionals
  • AS and related SpA have a predilection for inflammation at sites where the tendons and ligaments attach to the bones (enthesitis), especially in the sacroiliac joints and the spinal column. The symptoms usually start during late teens or early twenties (rarely after age 45), and is 2 to 3 times more common in males. (read full article)
Areas of Inflammation in Ankylosing Spondylitis
2012 July 9 Asim Radio Interview
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For Patients: What is Ankylosing Spondylitis a Nutshell?
Excerpted from: Ankylosing Spondyitis: the Facts Ankylosing Spondylitis

Ankylosing spondylitis (or “AS” for short) is a chronic (progressive) painful inflammatory rheumatic disease which affects the spinal joints, in particular those at the base of the spine (the sacroiliac (SI) joints  and the lumbar spine), with resultant chronic back pain and stiffness. These symptoms typically start at young age, beginning between the ages of 15 and 30; the mean age of onset is 24 years (range 8-45). It is very uncommon for the symptoms to begin after age 45. The most common first symptom is chronic low back pain and stiffness of gradual (insidious) onset. It can take many years, on average about 7 years, before the correct diagnosis. (read full article)

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